Ponsegromab is a monoclonal antibody commercialized by Pfizer, with a leading Phase II program in Congestive Heart Failure (Heart Failure). According to Globaldata, it is involved in 7 clinical trials, of which 5 were completed, and 2 are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of Ponsegromab’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
The revenue for Ponsegromab is expected to reach an annual total of $9 mn by 2040 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Ponsegromab Overview
Ponsegromab (PF-06946860) is under development for the treatment of cancer cachexia and heart failure. It is administered through subcutaneous route. The drug candidate acts by targeting growth/differentiation Factor 15 (GDF15). It is a new molecular entity.
Pfizer Overview
Pfizer discovers, develops, manufactures, and commercializes biopharmaceuticals. The company offers products to treat various conditions such as cardiovascular, metabolic and pain, women’s health, cancer, inflammation, immune disorders, and rare diseases. It also provides sterile injectable pharmaceuticals, biosimilars, active pharmaceutical ingredients (APIs) and contract manufacturing services. Pfizer sells its products through wholesalers, retailers, hospitals, individual provider offices, clinics, government agencies, and pharmacies. It has major manufacturing facilities in India, China, Japan, Ireland, Italy, Belgium, Germany, Singapore, and the US. The company provides its products in North America, South America, Asia-Pacific, Australia, Europe, Africa, and the Middle East. Pfizer is headquartered in New York, the US.
The company reported revenues of (US Dollars) US$58,496 million for the fiscal year ended December 2023 (FY2023), a decrease of 41.7% over FY2022. The operating loss of the company was US$929 million in FY2023, compared to an operating profit of US$36,237 million in FY2022. In FY2023, the company recorded a net margin of 3.6%, compared to a net margin of 31.3% in FY2022.
The company reported revenues of US$14,878 million for the first quarter ended March 2024, an increase of 4.4% over the previous quarter.
For a complete picture of Ponsegromab’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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