Pieris Pharmaceuticals has been granted a patent for a fusion polypeptide that targets both CD137 and GPC3, potentially aiding in the treatment of various tumors. The polypeptide comprises specific subunits for each target and can be used in anti-cancer and immune modulation therapies. GlobalData’s report on Pieris Pharmaceuticals gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Pieris Pharmaceuticals, Active contour based diagnosis models was a key innovation area identified from patents. Pieris Pharmaceuticals's grant share as of April 2024 was 45%. Grant share is based on the ratio of number of grants to total number of patents.
Fusion polypeptide binding cd137 and gpc3 for cancer treatment
A recently granted patent (Publication Number: US11919931B2) discloses a fusion polypeptide capable of binding both CD137 and glypican-3 (GPC3). The fusion polypeptide consists of at least two subunits, with the first subunit specific for CD137 and the second subunit specific for GPC3. The GPC3-specific lipocalin mutein within the fusion polypeptide contains mutated amino acid residues compared to the linear polypeptide sequence of mature human lipocalin 2 (hNGAL). Additionally, the patent specifies various sets of amino acid substitutions within the GPC3-specific lipocalin mutein, removing the natural N-glycosylation site at position 65.
Furthermore, the patent details that the GPC3-specific lipocalin mutein in the fusion polypeptide does not have an N-glycosylation site and can comprise specific amino acid sequences selected from a group of sequences provided in the patent. The fusion polypeptide can include specific amino acid sequences shown in SEQ ID NOs: 36 and 37, 38 and 39, 40 and 41, 42 and 43, 44, 45, 46, 47, or 53 and 54. These claims highlight the unique composition and specificity of the fusion polypeptide in targeting CD137 and GPC3, potentially offering novel therapeutic applications in the field of biotechnology and medicine.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
