Pelareorep is under clinical development by Oncolytics Biotech and currently in Phase II for Pancreatic Ductal Adenocarcinoma. According to GlobalData, Phase II drugs for Pancreatic Ductal Adenocarcinoma does not have sufficient historical data to build an indication benchmark PTSR for Phase II. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the Pelareorep LoA Report. Buy the report here.

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Data Insights Likelihood of Approval and Phase Transition Success Rate Model - Pelareorep in Pancreatic Ductal Adenocarcinoma

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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Pelareorep overview

Pelareorep (Reolysin) is under development for the treatment of metastatic breast cancer, HER2- breast cancer, refractory multiple myeloma, acute myelocytic leukemia, metastatic colorectal cancer, metastatic triple negative breast cancer, metastatic pancreatic cancer, metastatic colorectal cancer and unresectable anal cancer. The drug candidate is administered as injection or infusion through intravenous, intralesional, intratumoral, intraperitoneal and intrathecal route. Reolysin is a formulation of the human reovirus. It is reovirus type 3 without transgenes. The drug candidate was under development for the treatment of glioblastoma multiforme, relapsed multiple myeloma, ewing sarcoma, malignant fibrous histiocytoma, osteosarcoma, soft tissue sarcoma, fibrosarcoma, leiomyosarcoma, metastatic squamous cell carcinoma of the head and neck, recurrent and refractory astrocytoma, oligodendroglioma, high grade gliomas, medulloblastoma, primitive neuroectodermal tumor (PNET), gastric cancer, metastatic hormone-refractory prostate cancer and muscle-invasive bladder cancer, epithelial ovarian cancer, fallopian tube cancer, peritoneal cancer, advanced or metastatic squamous or non-squamous non-small cell lung cancer (NSCLC), metastatic adenocarcinoma of the pancreas, hepatocellular carcinoma and metastatic melanoma.

Oncolytics Biotech overview

Oncolytics Biotech (Oncolytics) is a biopharmaceutical company. It is developing pelareorep, an intravenous immunotherapeutic agent derived from a non-pathogenic reovirus. This treatment activates both innate and adaptive immune systems, enhancing anti-tumor responses and increasing susceptibility to various oncology treatments. The company is advancing pelareorep in hormone receptor-positive, HER2-negative metastatic breast cancer and metastatic pancreatic ductal adenocarcinoma. It is also exploring gastrointestinal cancers through its GOBLET platform study, having completed enrollment in cohorts for advanced pancreatic ductal adenocarcinoma, third-line colorectal cancer, and actively enrolling in an advanced anal cancer cohort. Oncolytics is headquartered in Calgary, Alberta, Canada.

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This content was updated on 12 April 2024

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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.