ORIC-533 is a small molecule commercialized by ORIC Pharmaceuticals, with a leading Phase I program in Relapsed Multiple Myeloma;Refractory Multiple Myeloma. According to Globaldata, it is involved in 2 clinical trials, of which 1 is ongoing, and 1 is planned. GlobalData uses proprietary data and analytics to provide a complete picture of ORIC-533’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for ORIC-533 is expected to reach an annual total of $261 mn by 2035 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
ORIC-533 Overview
ORIC-533 is under development for the treatment of relapsed or refractory multiple myeloma. These are administered through oral route. The drug candidates act by targeting CD73.
ORIC Pharmaceuticals Overview
ORIC Pharmaceuticals (ORIC) is a clinical-stage pharmaceutical company. It focuses on therapies to treat cancer. The company’s pipeline product pipeline includes ORIC-533, a orally bioavailable small molecule inhibitor for treatment of multiple myeloma; ORIC-114 to treat non-small cell lung cancer and breast and tumor agnostic; and ORIC-944 to treat prostate cancer. It also develops multiple drug programs for therapeutic areas of breast cancer, and solid tumors. ORIC is headquartered in South San Francisco, California, the US.
The operating loss of the company was US$110.8 million in FY2023, compared to an operating loss of US$91.8 million in FY2022. The net loss of the company was US$100.7 million in FY2023, compared to a net loss of US$89.1 million in FY2022.
For a complete picture of ORIC-533’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
