Orexo has filed a patent for a pharmaceutically-acceptable composition in the form of a spray-dried powder for transmucosal drug delivery. The composition includes a pharmacologically-active compound, carrier materials like disaccharides and polymeric materials, and may also contain alkyl saccharides. GlobalData’s report on Orexo gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Orexo, Cancer treatment biomarkers was a key innovation area identified from patents. Orexo's grant share as of January 2024 was 38%. Grant share is based on the ratio of number of grants to total number of patents.

Pharmaceutical composition for transmucosal drug delivery

Source: United States Patent and Trademark Office (USPTO). Credit: Orexo AB

A newly filed patent (Publication Number: US20240024244A1) describes a nasal applicator device designed for the intranasal delivery of a composition to the nasal mucosa. The device features a reservoir containing an amorphous powder formulation of epinephrine or its salt as the active ingredient, along with a carrier material comprising a disaccharide and a polymeric material. The powder is free of liquid propellant and water, ensuring efficient delivery of the medication to the nasal mucosa upon actuation. The composition's particle size and distribution are optimized for effective dosing, with specific requirements for water content, glass transition temperature, and particle size range.

Furthermore, the patent outlines various claims related to the composition of the amorphous powder, including the ratio of disaccharide to polymeric material, the inclusion of a sucrose ester, and the packaging of the device to prevent the ingress of atmospheric water. The process for manufacturing the nasal applicator device involves loading the amorphous powder into the device's reservoir. These claims highlight the unique formulation and design of the nasal applicator device, emphasizing its potential for precise and effective intranasal delivery of epinephrine or its salt for various medical applications.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies