OPC-1 is a cell therapy commercialized by Lineage Cell Therapeutics, with a leading Phase II program in Acute Spinal Cord Injury. According to Globaldata, it is involved in 3 clinical trials, of which 2 were completed, and 1 is planned. GlobalData uses proprietary data and analytics to provide a complete picture of OPC-1’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
Smarter leaders trust GlobalData
The revenue for OPC-1 is expected to reach an annual total of $32 mn by 2040 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
OPC-1 Overview
AST-OPC1 is under development for the treatment of acute and chronic spinal cord injury. It is administered through injection (parenteral). The therapeutic candidate contains human embryonic stem cells (hESCs)-derived from oligodendrocyte progenitor cells. The drug candidate was also under development for the treatment of Alzheimer's disease, Canavan disease, cerebral ischemia and multiple sclerosis .
Lineage Cell Therapeutics Overview
Lineage Cell Therapeutics (Lineage) formerly BioTime, is a clinical-stage biotechnology that develops new cell therapies for unmet medical needs. It develops products based on its core proprietary technology cell-based therapy platform. The company focuses on developing new cellular therapies for neurological conditions associated with demyelination and degenerative retinal diseases. Lineage’s major products include OpRegen, a cell therapy program for the treatment of ocular disorders, and OPC1, a cell therapy designed to improve recovery following a spinal cord injury. The company has an operational presence in the US and operates a manufacturing facility in Jerusalem, Israel. Lineage is headquartered in Carlsbad, California, the US.
The company reported revenues of (US Dollars) US$9 million for the fiscal year ended December 2023 (FY2023), a decrease of 39.2% over FY2022. The operating loss of the company was US$24.7 million in FY2023, compared to an operating loss of US$22.5 million in FY2022. The net loss of the company was US$21.5 million in FY2023, compared to a net loss of US$26.3 million in FY2022.
The company reported revenues of US$1.4 million for the second quarter ended June 2024, a decrease of 2.5% over the previous quarter.
For a complete picture of OPC-1’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
Data Insights
From
The gold standard of business intelligence.
Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors.
GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
