NKX-019 is under clinical development by Nkarta and currently in Phase I for Relapsed Chronic Lymphocytic Leukemia (CLL). According to GlobalData, Phase I drugs for Relapsed Chronic Lymphocytic Leukemia (CLL) have a 73% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how NKX-019’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
NKX-019 overview
NKX-019 is under development for the treatment of B-cell malignancies including B-cell non-Hodgkin lymphoma, chronic lymphocytic leukemia, relapsed or refractory chronic lymphocytic leukemia (CLL/SLL), follicular lymphoma, marginal zone b-cell lymphoma, mantle cell lymphoma, waldenstrom macroglobulinemia (lymphoplasmacytic lymphoma), diffuse large B-cell lymphoma, acute lymphoblastic leukemia, systemic sclerosis (scleroderma), idiopathic inflammatory myopathy (myositis) and ANCA-associated vasculitis (AAV). and lupus nephritis. The therapeutic candidate (CAR-NK) constitutes of genetically manipulated allogeneic NK cells which express a chimeric antigen receptor targeting tumor cells expressing B lymphocyte antigen CD19, transduced by gamma-retrovirus. It is administered through intravenous route.
Nkarta overview
Nkarta is a biopharmaceutical company that primarily focuses on the development of natural killer (NK) cell therapies for the treatment of cancer. The company’s main activities focus on leveraging proprietary technology to enhance the ability of NK cells to target and destroy tumor cells. Its products include NKX101 and NKX019, that are designed to activate specific receptors and signaling pathways in NK cells to boost their tumor-fighting capabilities. The company also carries out research and development and clinical trials. Nkarta is headquartered in South San Francisco, California, the US.
For a complete picture of NKX-019’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
