Nibrozetone is under clinical development by EpicentRx and currently in Phase II for Oral Mucositis. According to GlobalData, Phase II drugs for Oral Mucositis does not have sufficient historical data to build an indication benchmark PTSR for Phase II. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the Nibrozetone LoA Report. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Nibrozetone overview
Nibrozetone (RRX-001) is under development for the treatment of advanced solid tumors, radiation induced oral mucositis, small-cell lung cancer, endometriosis, acute radiation syndrome, Parkinson's disease, amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND), neuroprotection and toxic exposures. It is administered through intravenous, subcutaneous and as a hepatic artery infusion. The drug candidate is a dinitroazetidine radiosensitizer which acts by targeting NLRP3 and KEAP1. It is being developed based on CyNRGY platform.
The drug candidate was also under development for the treatment of advanced cholangiocarcinoma, refractory and relapsed multiple myeloma, recurrent or progressive malignant pediatric solid and central nervous system tumors, cerebral (fatal) malaria, metastatic hormone refractory (castration resistant, androgen-independent) prostate cancer, lymphoma, brain metastases, relapsed and refractory multiple myeloma, non-small cell lung cancer, epithelial ovarian cancer, fallopian tube cancer, primary peritoneal cancer, high grade neuroendocrine tumors, lymphoma, cerebral malaria, newly diagnosed high-grade glioma, including anaplastic glioma, glioblastoma, metastatic castration resistant neuroendocrine prostate cancer (NEPC), gliosarcoma, liver cancer, inflammation, metastatic colorectal cancer.
EpicentRx overview
EpicentRx is a biopharmaceutical company that focuses on developing novel therapies targeting inflammatory diseases and supportive care conditions with unmet medical needs. Its main activities include the development of investigational products such as RRx-001 and AdAPT-001. EpicentRx’s products are intended for use in treating a range of conditions, including cancer, neurodegenerative diseases, and endometriosis, serving healthcare providers and patients across various medical fields. The company’s brands include the PRETECT and AdAPT. It operates in the US. EpicentRx is headquartered in San Diego, California, the US.
For a complete picture of Nibrozetone’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
