Nerofe is under clinical development by Immune System Key and currently in Phase I for Alzheimer’s Disease. According to GlobalData, Phase I drugs for Alzheimer’s Disease have a 63% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how Nerofe’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Nerofe overview
Nerofe is under development for the treatment of advanced malignancies, solid tumors, myelodysplastic syndrome, Alzheimer''s disease and relapsed and refractory acute myelocytic leukemia (AML). The drug candidate is administered by intravenous route as an infusion. It is a derivative of the human hormone-peptide tumor-cells apoptosis factor (TCApF). It contains 14 amino-acids. The drug candidate acts by targeting IL1RL1. It was under development for the treatment of renal cell carcinoma, metastatic ovarian cancer, pancreatic cancer, triple negative breast cancer, metastatic colorectal carcinoma.
Immune System Key overview
Immune System Key (ISK) is a drug discovery and development company that focuses on treatments for malignant and autoimmune diseases. The company’s lead compound is NEROFE for the treatment of hematological disease acute myeloid leukemia (AML), solid tumors, pancreatic cancer, triple-negative (TN) breast cancer and Alzheimer’s. The company also offers several peptides and derivatives of natural human proteins which possess anti-cancer properties and the ability to regenerate several types of white blood cells. The company holds various patents on the molecule and applications. ISK is headquartered in Jerusalem, Israel.
For a complete picture of Nerofe’s drug-specific PTSR and LoA scores, buy the report here.
Data Insights
From
The gold standard of business intelligence.
Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors.
GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
