NB-4746 is under clinical development by Nura Bio and currently in Phase I for Amyotrophic Lateral Sclerosis. According to GlobalData, Phase I drugs for Amyotrophic Lateral Sclerosis have an 81% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how NB-4746’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
NB-4746 overview
NB-4746 is under development for the treatment of amyotrophic lateral sclerosis, multiple sclerosis (MS), traumatic brain injury (TBI), and chemotherapy-induced peripheral neuropathy (CIPN). The drug candidates act by targeting sterile alpha and TIR motif containing protein 1 (SARM1) protein. It is administered through oral route.
Nura Bio overview
Nura Bio is a clinical-stage biopharmaceutical company that develops neuroprotective small molecule therapies for the treatment of neurological diseases. The company’s lead product candidate, NB-4746 targets SARM1, a neuronally enriched nicotinamide adenine dinucleotide hydrolase that functions as a significant axon-intrinsic metabolic sensor and central driver of axon degeneration. It also develops therapies for various neurological diseases such as amyotrophic lateral sclerosis, multiple sclerosis, traumatic brain injury and chemotherapy-induced peripheral neuropathy. Nura Bio is headquartered in South San Francisco, California, the US.
For a complete picture of NB-4746’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
