Merus has been granted a patent for bispecific IgG antibodies that target CLEC12A and an immune effector cell antigen. The patent includes specific amino acid sequences for the heavy and light chain variable regions of the CLEC12A binding domain. GlobalData’s report on Merus gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Merus, Personalized cancer vaccines was a key innovation area identified from patents. Merus's grant share as of July 2024 was 27%. Grant share is based on the ratio of number of grants to total number of patents.
Bispecific igg antibodies targeting clec12a and immune cells
The patent US12060418B2 describes a CLEC12A binding domain characterized by specific amino acid sequences in its heavy and light chain variable regions. The heavy chain variable region includes multiple configurations of complementarity-determining regions (CDRs), specifically CDR1, CDR2, and CDR3, with defined sequences such as SGYTFTSY (SEQ ID NO: 1) and GTTGDWFDY (SEQ ID NO: 3). The light chain variable region is defined by its own set of CDRs, including RASQSISSYLN (SEQ ID NO: 17) and QQSYSTPPT (SEQ ID NO: 19). The claims also specify variations in the sequences that maintain at least 90% identity to certain reference sequences, allowing for flexibility in the binding domain's design.
Further claims detail the composition of the light chain variable region, which may include the human kappa light chain Ig V?1-39*01/IGJ?1*01. The patent also outlines specific heavy chain variable region sequences that can be used, emphasizing the importance of maintaining a high degree of sequence identity to the provided reference sequences. The claims collectively highlight the potential for creating a versatile CLEC12A binding domain with applications in therapeutic and diagnostic contexts, leveraging the defined sequences to ensure effective binding and functionality.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
