Larsucosterol sodium is under clinical development by DURECT and currently in Phase II for Alcoholic Hepatitis. According to GlobalData, Phase II drugs for Alcoholic Hepatitis does not have sufficient historical data to build an indication benchmark PTSR for Phase II. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the Larsucosterol sodium LoA Report. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Larsucosterol sodium overview
DUR-928 (DV-928) is under development for the treatment of alcoholic hepatitis, nonalcoholic fatty liver disease (NAFLD), non alcoholic steatohepatitis (NASH), alcoholic steatohepatitis (ASH), alcoholic fatty liver disease (AFLD), chronic kidney disease and acute kidney injury (AKI). It is a small molecule and new chemical entity (NCE). The drug candidate is formulated as both solution and suspension and is administered through oral, intralesional, intramuscular injection and topical routes. The drug candidate is a sulfated oxysterol. It acts by targeting DNMTs, DNMT-1, 3a and 3b.
It was under development for primary sclerosing cholangitis (PSC) and for mild to moderate plaque psoriasis and inflammatory skin conditions like atopic dermatitis. It was also under development for the treatment of COVID-19 patients with acute pneumonia, lung injury, liver or kidney injury.
DURECT overview
DURECT is a biopharmaceutical company that focuses on the development of novel therapeutic approaches through epigenetic modulation. The company develops, and commercializes drugs for life-threatening conditions such as acute organ injury and cancer. DURECT‘s major products include larsucosterol, an epigenetic modulator for acute organ injury and chronic liver disease, and POSIMIR, a bupivacaine solution for post-surgical analgesia. The company also manufactures and sells ALZET osmotic pumps, a product line used for experimental research in laboratory animals. The company’s products are used by researchers, physicians, and patients across the healthcare industry. It collaborates with various partners, including Innocoll Pharmaceuticals and Orient Pharma, for the development and commercialization of its products. The company has an operational presence in the US, Australia, Europe, and the UK. DURECT is headquartered in Cupertino, California, the US.
For a complete picture of Larsucosterol sodium’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
