JZP-898 is a fusion protein commercialized by Jazz Pharmaceuticals, with a leading Phase I program in Metastatic Transitional (Urothelial) Tract Cancer. According to Globaldata, it is involved in 1 clinical trial, which is ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of JZP-898’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for JZP-898 is expected to reach an annual total of $16 mn by 2040 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
JZP-898 Overview
JZP-898 is under development for the treatment of relapsed and refractory metastatic solid tumors, non-small cell lung cancer, melanoma, head and neck squamous cell carcinoma, renal cell carcinoma, hepatocellular carcinoma, gastroesophageal carcinomas, urothelial cell carcinoma, colorectal carcinoma and hematological malignancies. The drug candidate is a fusion polypeptide comprises of IFN alpha polypeptide and the IFN alpha-blocking moiety linked by the protease-cleavable polypeptide linker. It is being developed based on protein engineering technology (PREDATOR). It is administered through intravenous route.
Jazz Pharmaceuticals Overview
Jazz Pharmaceuticals is a specialty biopharmaceutical company which identifies, develops, and commercializes medicines with focus on narcolepsy, cancer, pain, and psychiatry. Its marketed products include Xyrem (sodium oxybate) oral solution, Sunosi (solriamfetol), Erwinaze (asparaginase erwinia chrysanthemi), Defitelio (defibrotide sodium), Vyxeos (daunorubicin and cytarabine) liposome for injection, and others. The company also has various pipeline product candidates related to focus areas such as sleep, neurological disorders, hematology, and oncology including hematologic malignancies and solid tumors. The company sells its products through a network of local distributors and wholesalers. It has operations in the US and Europe. Jazz Pharmaceuticals is headquartered in Dublin, Ireland.
The company reported revenues of (US Dollars) US$3,834.2 million for the fiscal year ended December 2023 (FY2023), an increase of 4.8% over FY2022. The operating profit of the company was US$578.6 million in FY2023, compared to an operating loss of US$65.5 million in FY2022. The net profit of the company was US$414.8 million in FY2023, compared to a net loss of US$224.1 million in FY2022.
The company reported revenues of US$902 million for the first quarter ended March 2024, a decrease of 10.9% over the previous quarter.
For a complete picture of JZP-898’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
