JCR Pharmaceuticals has developed a bifunctional fusion antibody designed to treat iduronate 2-sulfatase deficiency in the central nervous system. This antibody crosses the blood-brain barrier and retains significant enzymatic activity, facilitating the hydrolysis of specific sulfate groups in glycosaminoglycans. GlobalData’s report on JCR Pharmaceuticals gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on JCR Pharmaceuticals, Nanoparticle drug conjugates was a key innovation area identified from patents. JCR Pharmaceuticals's grant share as of July 2024 was 49%. Grant share is based on the ratio of number of grants to total number of patents.
Fusion antibody for treating iduronate 2-sulfatase deficiency
The granted patent US12043661B2 describes a novel fusion antibody designed to effectively cross the blood-brain barrier (BBB) and deliver therapeutic benefits. The fusion antibody comprises an immunoglobulin heavy chain or a fragment thereof, covalently linked to an iduronate-2-sulfatase with a specific amino acid sequence (SEQ ID NO: 9). This unique structure allows the fusion protein to utilize the transferrin receptor for BBB penetration while maintaining at least 20% of the iduronate-2-sulfatase's enzymatic activity compared to its standalone form. The antibody is also capable of catalyzing the hydrolysis of 2-sulfate groups from L-iduronate 2-sulfate units found in dermatan sulfate, heparan sulfate, or heparin.
Further claims detail enhancements to the fusion antibody, including the potential incorporation of an immunoglobulin light chain, which may be of either lambda or kappa class. The patent also specifies that the fusion antibody can be post-translationally modified by a sulfatase modifying factor type 1 (SUMF1) to improve its efficacy. Notably, the fusion antibody demonstrates a specific activity of at least 10,000 units/mg for the iduronate-2-sulfatase and retains significant activity after crossing the BBB and entering lysosomal compartments in central nervous system cells. Additionally, it has been shown to reduce glycosaminoglycan (GAG) accumulation in Hunter fibroblasts, indicating its potential therapeutic application in treating related disorders.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
