Istisociclib is a small molecule commercialized by Kronos Bio, with a leading Phase II program in Germ Cell Tumors;Uterine Cancer;Epithelial Ovarian Cancer. According to Globaldata, it is involved in 1 clinical trial, which is ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of Istisociclib’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for Istisociclib is expected to reach an annual total of $91 mn by 2036 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Istisociclib Overview
Istisociclib (KB-0742) is under development for the treatment of castration resistant prostate cancer, soft tissue sarcoma and MYC-dependent acute myeloid leukemia, solid tumors, ovarian cancer, chordoma, non-Hodgkin lymphoma, soft tissue sarcoma, bladder cancer, rectal cancer , germ cell tumors; uterine cancer, colorectal cancer, myxoid liposarcoma, non-small cell lung cancer (NSCLC), small-cell lung cancer (SCLC), triple-negative breast cancer (TNBC), gastric cancer, gastroesophageal (GE) junction carcinomas, diffuse large B-cell carcinoma, NUT midline carcinoma, adenoid cystic carcinoma, neuroblastoma tumors, ewing sarcoma (EW) and alveolar rhabdomyosarcoma (ARMS). It is administered through oral route as a capsule. The drug candidate acts by targeting cyclin-dependent kinase 9 (CDK9). It is developed based on small molecule microarray (SMM) platform.
Kronos Bio Overview
Kronos Bio is a clinical-stage biopharmaceutical company that discovers and develops therapeutics for cancer and other serious diseases. The company pipeline products include KB-0742, an oral cyclin-dependent kinase 9 (CDK9) inhibitor for the treatment of MYC-amplified and other transcriptionally addicted solid tumors, and KB-9558, which inhibits the lysine acetyltransferase (KAT) domain of p300, a critical node of the IRF4 TRN. It collaborates with other companies for research and development. The company operates in Massachusetts and California. Kronos Bio is headquartered in San Mateo, California, the US.
The company reported revenues of (US Dollars) US$6.3 million for the fiscal year ended December 2023 (FY2023). The operating loss of the company was US$121.8 million in FY2023, compared to an operating loss of US$137.1 million in FY2022. The net loss of the company was US$112.7 million in FY2023, compared to a net loss of US$133.2 million in FY2022.
For a complete picture of Istisociclib’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
