Inupadenant hydrochloride is a small molecule commercialized by iTeos Therapeutics, with a leading Phase II program in Endometrial Cancer. According to Globaldata, it is involved in 6 clinical trials, of which 1 was completed, and 5 are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of Inupadenant hydrochloride’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for Inupadenant hydrochloride is expected to reach an annual total of $92 mn by 2035 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Inupadenant hydrochloride Overview
EOS-850 is under development for the treatment of solid tumors, triple-negative breast cancer, checkpoint inhibitor-refractory melanoma and in a patient with metastatic hormone, head and neck cancer squamous cell carcinoma, non-small cell lung cancer, endometrial cancer and chemotherapy resistant prostate cancer. The drug candidate is a small molecule that acts by targeting adenosine receptor A2A. It is administered through oral route.
iTeos Therapeutics Overview
iTeos Therapeutics is a clinical-stage biopharmaceutical company. It discovers and develops immuno-oncology drugs for cancer. The company’s pipeline products are EOS-448, EOS-984, dostarlimab, iberdomide, pembrolizumab, CD96 drug candidates. Its products are used to treat various cancers like advanced malignancies, relapsed refractory multiple myeloma. The drug candidates either in monotherapy or in combination with additional drugs, as well as in intraportfolio combinations. Its service includes to carries out clinical trials for inupadenant, an A2A receptor antagonist, as a treatment for solid tumors in monotherapy. It has operational presence in the US; and Belgium. iTeos Therapeutics is headquartered in Cambridge, Massachusetts, the US.
The company reported revenues of (US Dollars) US$12.6 million for the fiscal year ended December 2023 (FY2023), a decrease of 95.3% over FY2022. The operating loss of the company was US$151.1 million in FY2023, compared to an operating profit of US$126.3 million in FY2022. The net loss of the company was US$112.6 million in FY2023, compared to a net profit of US$96.7 million in FY2022.
For a complete picture of Inupadenant hydrochloride’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
