Idorsia Pharmaceutical. has filed a patent for novel crystalline forms of {5-(4-bromo-phenyl)-6-[2-(5-bromo-pyrimidin-2-yloxy)-ethoxy]-pyrimidin-4-yl}-sulfamide, their preparation processes, pharmaceutical compositions, and use as endothelin receptor antagonists. The patent also covers new uses of the compound alone or in combination with other therapeutic agents. GlobalData’s report on Idorsia Pharmaceutical gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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Novel crystalline forms of endothelin receptor antagonist
A pharmaceutical patent application (Publication Number: US20230391757A1) describes a novel pharmaceutical unit dosage form for oral administration. The dosage form includes a crystalline form of {5-(4-bromo-phenyl)-6-[2-(5-bromo-pyrimidin-2-yloxy)-ethoxy]-pyrimidin-4-yl}-sulfamide. This solid dosage form contains specific ingredients in defined amounts, such as microcrystalline cellulose, lactose, hydroxypropylcellulose, croscarmellose sodium, and magnesium stearate. The crystalline form of the active ingredient is characterized by specific peaks in the X-ray powder diffraction diagram, indicating its unique structure.
Furthermore, the patent application details the process for preparing this pharmaceutical composition, involving mixing the crystalline form of the active ingredient with the specified excipients. The dosage form is designed to deliver 10 to 50 mg per day of {5-(4-bromo-phenyl)-6-[2-(5-bromo-pyrimidin-2-yloxy)-ethoxy]-pyrimidin-4-yl}-sulfamide. The X-ray powder diffraction diagram of the crystalline form is crucial for confirming its identity and purity, with specific peaks at defined angles of refraction. This innovative dosage form, presented as a tablet, offers a precise and effective way of administering the active ingredient for potential therapeutic applications.
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