The Histone Lysine N Methyltransferase EZH2 pipeline drugs market research report outlays comprehensive information on the Histone Lysine N Methyltransferase EZH2 targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA), and molecule type. GlobalData’s report assesses the drugs in the Histone Lysine N Methyltransferase EZH2 pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline. Buy the report here.
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The report also covers products from therapy areas such as Oncology, and Infectious Disease which include the indications Diffuse Large B-Cell Lymphoma, Solid Tumor, and Respiratory Syncytial Virus (RSV) Infections. It also reviews key players involved in Histone Lysine N Methyltransferase EZH2 targeted therapeutics development with respective active and dormant or discontinued products.
The Histone Lysine N Methyltransferase EZH2 pipeline targets constitutes close to 24 molecules. Out of which, approximately 19 molecules are developed by companies and the remaining by the universities/institutes. The molecules developed by companies in Pre-Registration, Phase III, Phase II, Phase I, Preclinical, and Discovery stages are 1, 1, 6, 2, 5, and 4 respectively. Similarly, the universities portfolio in Preclinical, and Discovery comprises 2, and 3 molecule.
Histone Lysine N Methyltransferase EZH2 overview
Enhancer of zeste homolog 2 (EZH2) is a histone-lysine N-methyltransferase enzyme encoded by EZH2 gene. EZH2 methylates non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA. It regulates the circadian clock via histone methylation at the promoter of the circadian genes. It is essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-ARNTL/BMAL1 heterodimer, involved in the di and trimethylation of Lys-27 of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription.
For a complete picture of Histone Lysine N Methyltransferase EZH2’s drug pipeline, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
Global Markets Direct’s report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third-party sources.
Drug profiles featured in the report undergo periodic review following a stringent set of processes to ensure that all the profiles are updated with the latest set of information. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.
