Golcadomide is a small molecule commercialized by Bristol-Myers Squibb, with a leading Phase II program in Primary CNS Lymphoma. According to Globaldata, it is involved in 13 clinical trials, of which 2 were completed, 8 are ongoing, and 3 are planned. GlobalData uses proprietary data and analytics to provide a complete picture of Golcadomide’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for Golcadomide is expected to reach an annual total of $32 mn by 2036 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Golcadomide Overview
Golcadomide hydrochloride (CC-99282) is under development for the treatment of relapsed or refractory, non-Hodgkin lymphoma, diffuse large B cell lymphoma, primary mediastinal B-cell lymphoma, marginal zone b-cell lymphoma, unspecified B-cell lymphomas, follicular lymphoma, relapsed or refractory chronic lymphocytic leukemia (small lymphocytic lymphoma) and T-cell lymphomas. The drug candidate is administered by oral route and is a next-generation molecular glue CELMoD compound (cereblon E3 ligase modulation drugs) which acts by targeting cereblon protein.
Bristol-Myers Squibb Overview
Bristol-Myers Squibb (BMS) is a specialty biopharmaceutical company that is engaged in discovery, development, licensing and manufacturing, marketing, distribution and sale of medicines and related medical products to patients with serious diseases. Its primary focus is on cancer, cardiovascular, immunology and fibrotic therapeutic projects. The company offers its products across the world to wholesalers, retail pharmacies, medical professionals, hospitals and government entities. BMS provides its products in the US, Europe, and Japan. The company conducts research to focus on the discovery and development of novel medicines that address serious diseases in areas of significant unmet medical need. BMS is headquartered in Princeton, New Jersey, the US.
For a complete picture of Golcadomide’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
