Fibromun is under clinical development by Philogen and currently in Phase II for Malignant Glioma. According to GlobalData, Phase II drugs for Malignant Glioma does not have sufficient historical data to build an indication benchmark PTSR for Phase II. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the Fibromun LoA Report. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Fibromun overview
Fibromun (L19-TNF alpha monoclonal antibody-cytokine fusion protein) is under development for the treatment of stage III and IV unresectable melanoma patients, newly diagnosed glioblastoma, soft tissue sarcoma, leiomyosarcoma, malignant glioma, glioma and advanced solid tumors. It is administered through intravenous route as a solution. It is a fully-human vascular targeting immunocytokine consisting of human pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) fused to a human single-chain variable fragment (scFv) directed against the extra-domain B (ED-B) of fibronectin (L19). It is developed based on immunocytokine technology. It was also under development for the treatment of colorectal cancer and melanoma in combination with melphalan, malignant fibrous histiocytoma, myxoid liposarcoma, round cell liposarcoma, pleomorphic liposarcoma, dedifferentiated liposarcoma, liposarcoma, pleomorphic liposarcoma, pleomorphic rhabdomyosarcoma, myxofibrosarcoma intermediate and high-grade, fibrosarcoma, angiosarcoma, alveolar rhabdomyosarcoma.
Philogen overview
Philogen is a biotechnology company that develops biopharmaceuticals for the treatment of angiogenesis-related disorders. The company’s product portfolio include Dodekin, Dekavil, NidlegyTM, Fibromun, Darleukin, and ABBV-022. The company provides dekavil and tetravil and others targeted at the treatment of severe pathologies such as cancer, rheumatoid arthritis and age-related macular degeneration. It offers DNA-encoded chemical libraries, antibody drug conjugates, immunocytokines, and antibody libraries, discovery of vascular targets, vascular targeting and easy iodine technology. The company is also advancing clinical development programs for the treatment of cancer and of chronic diseases. Philogen is headquartered in Siena, Italy.
For a complete picture of Fibromun’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
