Enzo Biochem has been granted a patent for a method of making reduced background multi-well microtiter plates for use in ligand-binding assays. The invention involves coating the inner surface of protein-binding wells with a low protein-binding coating material and selectively removing the coating from only part of the coated surface. This innovation aims to improve the accuracy and sensitivity of enzyme-linked immunosorbent assays (ELISAs) and other ligand-binding assays. GlobalData’s report on Enzo Biochem gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Enzo Biochem, Cancer treatment biomarkers was a key innovation area identified from patents. Enzo Biochem's grant share as of September 2023 was 54%. Grant share is based on the ratio of number of grants to total number of patents.
Reduced background multi-well microtiter plate for ligand-binding assays
A recently granted patent (Publication Number: US11745184B1) describes a method for producing a reduced background multi-well microtiter plate for use in ligand-binding assays. The method involves several steps to achieve this reduction in background signal.
The first claim of the patent outlines the method, which includes providing a multi-well microtiter plate with protein-binding inner surfaces. The next step involves coating at least one of the wells with a low protein-binding coating material. However, the coating is only removed from part of the coated surface, leaving some areas still coated.
The second claim specifies that the coating is predominantly not removed from the side walls of the coated well(s), but may be removed from part or all of the bottom of the well(s). This selective removal of the coating helps to further reduce the background signal in the microtiter plate.
The third claim presents an alternative method for producing the reduced background multi-well microtiter plate. In this method, the plate itself is composed of a protein-binding material, ensuring that the inner surface of at least some of the wells is protein-binding. A liquid containing a low protein-binding coating material is added to the well(s), coating both the bottom and side walls up to a preselected height or substantially to the top. The liquid is then removed from the well(s), and a solvent is added to selectively remove the coating from only part of the coated surface. Finally, the added solvent is removed from the well(s).
Similar to the second claim, the fourth claim emphasizes that the coating is predominantly not removed from the side walls of the coated well(s), but may be removed from part or all of the bottom of the well(s).
Overall, this granted patent describes methods for producing a reduced background multi-well microtiter plate for ligand-binding assays. By selectively coating and removing the coating from specific areas of the wells, the background signal is minimized, improving the accuracy and sensitivity of the assays conducted using these plates.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
