Emicizumab is under clinical development by Chugai Pharmaceutical and currently in Phase I for Von Willebrand Disease (vWD). According to GlobalData, Phase I drugs for Von Willebrand Disease (vWD) have a 100% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how Emicizumab’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Emicizumab overview
Emicizumab (Hemlibra / RG-6013 / ACE-910) is a humanized monoclonal modified immunoglobulin G4 (IgG4) bi-specific antibody acts as an anti-factor IXa- and anti-factor X or anti-haemophilic agent. It is formulated as injectable solution for subcutaneous route of administration. Hemlibra is indicated for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients with hemophilia A (congenital factor VIII deficiency) with factor VIII inhibitors, and also indicated for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients ages, newborn and older with hemophilia A (congenital factor VIII deficiency) with or without factor VIII inhibitors. Hemlibra is indicated for the routine prophylaxis to prevent or reduce the frequency of bleeding episodes in patients with acquired hemophilia A.
Emicizumab is under development for the treatment of acquired mild to moderate hemophilia A and Von Willebrand Disease (vWD).
Chugai Pharmaceutical overview
Chugai Pharmaceutical (Chugai), a subsidiary of F. Hoffmann-La Roche Ltd, specializes in biotechnological research and drug manufacturing. The company manufactures, markets, exports and imports pharmaceutical products in Japan and other countries. The company offers products for the treatment of various therapeutic areas including, cancer; bone and joint diseases; renal diseases; immune disorders and infectious diseases and others. It also offers drugs to aid the kidney, liver and other organ transplants. The company is operating through its network of subsidiaries, the company offers its pharmaceutical products in overseas markets including North America, Europe and Asia. Chugai is headquartered in Chuo-ku, Tokyo, Japan.
For a complete picture of Emicizumab’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
