EBTATE is under clinical development by Molecular Targeting Technologies and currently in Phase I for Neuroendocrine Gastroenteropancreatic Tumors (GEP-NET). According to GlobalData, Phase I drugs for Neuroendocrine Gastroenteropancreatic Tumors (GEP-NET) have a 97% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how EBTATE’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
EBTATE overview
177-Lu-DOTA-EB-TATE is under development for the treatment of neuroendocrine tumors, metastatic gastroenteropancreatic neuroendocrine tumors (GEP-NETs), Hurthle cell thyroid cancer and nasopharyngeal cancer. 177Lu-DOTA-TATE is administered as an intravenous infusion. It is a radioligand therapy consisting of somatostatin analog octreotide conjugated to radioisotope 177 lutetium via the chelator 1,4,7,10- tetraazacyclododecane-N,N’,N”, N”’-tetraacetic acid (DOTA). The drug candidate acts by targeting Somatostatin Receptor Type 2.
It was also under development for hematological tumors.
Molecular Targeting Technologies overview
Molecular Targeting Technologies (MTTI) is a biotechnology company that develops novel technologies for the treatment and diagnosis of human diseases. The company offers therapeutic pipelines including rabies mab, BPRDP056, EBTATE, EBRGD, TDURA, and cypH-11. used for the treatment of rabies, multiple cancers, neuroendocrine tumors, hurthle cell thyroid cancer, nasopharyngeal cancer, glioblastoma multiforme, non-small cell lung cancer, colorectal cancer, and peritoneal cancer. MTTI offers products like dyes for bioconjugation, lipophilic cyanines, dyes for bioconjugation, immobilized steroid beads, optical imaging agents, crosslinkers, research products and others. It provides custom chemistry services for pharmaceutical companies. MTTI is headquartered in West Chester, Pennsylvania, the US.
For a complete picture of EBTATE’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
