Devimistat is under clinical development by Cornerstone Pharmaceuticals and currently in Phase II for Unspecified B-Cell Lymphomas. According to GlobalData, Phase II drugs for Unspecified B-Cell Lymphomas does not have sufficient historical data to build an indication benchmark PTSR for Phase II. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the Devimistat LoA Report. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Devimistat overview
Devimistat (CPI-613) is under development for the treatment of Burkitt lymphoma or High-grade B-cell Lymphoma, metastatic pancreatic cancer, gallbladder cholangiocarcinoma, extrahepatic cholangiocarcinoma, intrahepatic cholangiocarcinoma as first line of therapy, metastatic biliary tract cancer, hematologic malignancies including ewing sarcoma, relapsed or refractory granulocytic sarcoma, peripheral T-cell lymphoma, relapsed or refractory T-cell Hodgkin lymphoma, T-cell non-Hodgkin lymphoma, pancreatic cancer and colorectal cancer. It is administered as an intravenous infusion. CPI-613 is an analogue of alpha-lipoic acid that targets the mitochondrial enzymes pyruvate dehydrogenase (PDH) and alpha-ketoglutarate dehydrogenase. The drug candidate is based on altered energy metabolism directed (AEMD) drug platform. It was also under development for the treatment of relapsed or refractory B-cell non-Hodgkin lymphoma, pancreatic ductal adenocarcinoma, non-small cell lung cancer and solid tumors. It was under development for extrahepatic cholangiocarcinoma, intrahepatic cholangiocarcinoma, and metastatic cholangiocarcinoma (bile duct cancer), relapsed or refractory myelodysplastic syndrome, relapsed or refractory acute myelocytic leukemia (AML) as second line of therapy, and pancreatic ductal adenocarcinoma as first line therapy, metastatic colorectal cancer and soft tissue sarcoma.
Cornerstone Pharmaceuticals overview
Cornerstone Pharmaceuticals (Cornerstone), a subsidiary of Rafael Holdings Inc, is a metabolic oncology therapeutics company. Its pipeline products include CPI 613 (devimistat) and CB 839 (telaglenastat). The company’s devimistat target cancer cell mitochondria treat solid tumors and blood cancers; telaglenastat is a potent and selective reversible inhibitor of glutaminase activity that target cancer. It utilizes an altered metabolism-directed (AMD) platform to split biochemical alterations and develop drugs. The company collaborates with researchers, companies, and universities to produce and research the pipeline medicines. Cornerstone is headquartered in Cranbury, New Jersey, the US.
For a complete picture of Devimistat’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
