CX-2051 is under clinical development by CytomX Therapeutics and currently in Phase I for Metastatic Colorectal Cancer. According to GlobalData, Phase I drugs for Metastatic Colorectal Cancer have an 84% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how CX-2051’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
CX-2051 overview
CX-2051 is under development for the treatment of Ep-CAM expressing epithelial cancers, solid tumors and metastatic colorectal cancer. The therapeutic candidate is a conditionally activated antibody drug conjugate (ADC) which acts by targeting cells expressing epithelial cell adhesion molecule (EpCAM) and has a camptothecin derivative payload which acts by targeting topoisomerase-1. It is being developed based on PROBODY therapeutic platform.
CytomX Therapeutics overview
CytomX Therapeutics (Cytomx) is a clinical-stage biopharmaceutical company. It develops novel therapeutic antibodies and Probody therapeutics for the treatment of cancer. The company’s product pipeline include CX-2029, CX-904 and BMS-986288. Its pipeline carries out SqNSCLC, esophageal/GEJ and solid tumors. Cytomx provides probody therapeutics for the treatment of cancer. The company also carries out various phases of clinical trails. Cytomx is headquartered in South San Francisco, California, the US.
For a complete picture of CX-2051’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
