CSPC Pharmaceutical Group has been granted a patent for a pharmaceutical composition targeting Cx43 hemichannels in astrocytes or osteocytes to treat inflammatory or neurodegenerative diseases like spinal cord injury. The formulation includes specific antibodies and stabilizing agents within a defined pH range. GlobalData’s report on CSPC Pharmaceutical Group gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on CSPC Pharmaceutical Group, Anti-bacterial thiazole derivatives was a key innovation area identified from patents. CSPC Pharmaceutical Group's grant share as of April 2024 was 50%. Grant share is based on the ratio of number of grants to total number of patents.
Pharmaceutical formulation for treating inflammatory or neurodegenerative diseases
A recently granted patent (Publication Number: US11912764B2) discloses a pharmaceutical formulation designed to inhibit the opening of Cx43 hemichannels in cells. The formulation includes an anti-Cx43 antibody or antigen binding fragment, a buffer, a surfactant, and a stabilizer, with a pH range of 5 to 6. The antibody component comprises specific heavy and light chain complementarity determining region (CDR) sequences, with further variations in heavy chain variable domain sequences specified in the claims.
Moreover, the patent details the specific composition of the pharmaceutical formulation, including the concentration of the anti-Cx43 antibody, buffer selection (such as histidine/aspartic acid or histidine/histidine hydrochloride), the surfactant (polysorbate 80), and the stabilizer (sucrose). The pH range of the formulation is specified to be between 5.4 to 5.6, emphasizing its aqueous nature. The patent also outlines a method for administering the formulation to treat inflammatory or neurodegenerative diseases, highlighting its potential therapeutic applications in these conditions.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
