CLN-619 is a monoclonal antibody commercialized by Cullinan Therapeutics, with a leading Phase I program in Metastatic Transitional (Urothelial) Tract Cancer. According to Globaldata, it is involved in 2 clinical trials, of which 1 is ongoing, and 1 is planned. GlobalData uses proprietary data and analytics to provide a complete picture of CLN-619’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for CLN-619 is expected to reach an annual total of $75 mn by 2040 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
CLN-619 Overview
CLN-619 is under development for the treatment of solid tumors such as Non-small cell lung cancer, cervical cancer, ovarian cancer, head and neck cancer squamous cell carcinoma, colon cancer, prostate cancer and metastatic urothelial carcinoma. The therapeutic candidate is a anti-MICA humanized IgG1 monoclonal antibody and acts by targeting MHC class I polypeptide related sequence A (MICA) and MHC class I polypeptide related sequence B (MICB). It is administered by intravenous route.
It was also under development for liver cancer.
Cullinan Therapeutics Overview
Cullinan Therapeutics, formerly Cullinan Oncology Inc, is clinical-stage biotechnology company. It focuses on the discovery and development of oncology therapies. Its product pipeline includes CLN-081 for the treatment of non-small cell lung cancer; CLN-619 against pan-cancer; and CLN-049 to treat relapsed and refractory acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS). Cullinan Therapeutic;s pipeline also includes drug programs such as CLN-418 for multiple solid tumors; CLN-978 to treat B-cell non-Hodgkin lymphomas and CLN-617 for treatment of pan-cancer. The company also provides various patient support programs. Cullinan Therapeutics is headquartered in Cambridge, Massachusetts, the US.
The operating loss of the company was US$191.1 million in FY2023, compared to an operating profit of US$144.7 million in FY2022. The net loss of the company was US$153.2 million in FY2023, compared to a net profit of US$111.2 million in FY2022.
For a complete picture of CLN-619’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
