Cellectis has been granted a patent for a hexaploid Triticum plant engineered to have increased dietary fiber levels. This is achieved through TALE nuclease-induced mutations in starch branching enzyme IIa alleles, while maintaining wild-type starch branching enzyme IIb alleles. GlobalData’s report on Cellectis gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Cellectis, CAR-T cell based therapies was a key innovation area identified from patents. Cellectis's grant share as of June 2024 was 37%. Grant share is based on the ratio of number of grants to total number of patents.
Increased dietary fiber in hexaploid triticum plants
The granted patent US12012607B2 describes a hexaploid Triticum plant, plant part, or plant cell that has been genetically modified to include at least three deletion or insertion mutations in the starch branching enzyme IIa (SBEIIa) alleles. These mutations are induced by a transcription activator-like effector (TALE) nuclease, specifically designed to bind to a defined nucleic acid sequence. The resulting Triticum plant exhibits increased levels of dietary fiber compared to control plants that do not have these mutations. The patent outlines that the SBEIIb alleles remain wild-type, and the mutations are homozygous across the A, B, and D genomes of the plant.
Additionally, the patent details methods for generating such modified Triticum plants, which include transforming plant cells or parts with the TALE nuclease. The methods can involve various plant tissues, such as protoplasts, immature embryos, or embryogenic callus, and may utilize techniques like Agrobacterium-mediated transformation or biolistics. The resulting plants not only show enhanced dietary fiber content but also may have increased starch content with a higher proportion of amylose and total protein compared to unmodified controls. The claims further specify the sequences of the mutant alleles and the specific positions of deletions, providing a comprehensive framework for the genetic modifications aimed at improving the nutritional profile of Triticum species, particularly Triticum aestivum.
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