CD19 t-haNK is under clinical development by ImmunityBio and currently in Phase I for B-Cell Non-Hodgkin Lymphoma. According to GlobalData, Phase I drugs for B-Cell Non-Hodgkin Lymphoma have a 75% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how CD19 t-haNK’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
CD19 t-haNK overview
Gene therapy was under development for the treatment of acute lymphocytic leukemia (ALL), follicular lymphoma and diffuse large B-cell lymphoma. The therapeutic candidate comprises tumor attacking natural killer cells (TANK) expressing chimeric antigen receptors (CAR-NK) targeting CD19. It is administered through parenteral route as suspension.
It is under development for the treatment of relapsed and refractory B-cell non Hodgkin lymphoma.
ImmunityBio overview
ImmunityBio, a subsidiary of NantWorks LLC, is a clinical-stage biotechnology company developing therapies for therapies for cancer and infectious diseases. The company product pipeline includes anktiva + BCG, anktiva + keytruda (pembrolizumab), aldox + anktiva + PD-L1 t-hank, anktiva + tri-ad5 vaccines, anktiva + bevacizumab + PD-L1 t-hank, anktiva + IBRX-042 vaccination, anktiva + M-ceNK and anktiva + CD19 t-haNK. ImmunityBio pipeline candidates treat bladder cancer, lung cancer, lynch syndrome, pancreatic cancer, glioblastoma, HPV, advanced Solid tumors, non-hodgkin lymphoma and HIV. The company operates in Italy, South Korea and the US. ImmunityBio is headquartered in San Diego, California, the US.
For a complete picture of CD19 t-haNK’s drug-specific PTSR and LoA scores, buy the report here.
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