Caficrestat is under clinical development by Applied Therapeutics and currently in Phase III for Cardiomyopathy. According to GlobalData, Phase III drugs for Cardiomyopathy have a 57% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData’s report assesses how Caficrestat’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Caficrestat overview
Caficrestat (AT-001) is under development for the treatment of diabetic complications including type 2 diabetes, diabetic cardiomyopathy, diabetic peripheral neuropathy, acute myocardial infarction (liquid formulation), acute lung inflammation and cardiomyopathy in critical COVID-19 infections. The drug candidate acts by targeting aldose reductase. It is administered through an oral and subcutaneous route. It was under development for congestive heart failure in adults.
Applied Therapeutics overview
Applied Therapeutics is a clinical-stage biopharmaceutical company that focuses on developing transformative drugs in areas Galactosemia and Diabetic Cardiomyopathy (DbCM). The company product pipeline includes include AT-001 a novel aldose reductase inhibitor, AT-007 a SORD Deficiency, AT-001 a Diabetic Peripheral Neuropathy. It also develops preclinical pipeline product AT-003, an ARI designed for the treatment of diabetic retinopathy and AT-104 a PI3K inhibitor for treating orphan hematological oncology T Cell Acute Lymphoblastic Leukaemia. It serves in the United States. Applied Therapeutics is headquartered in New York City, New York, the US.
For a complete picture of Caficrestat’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
