GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.

Cadonilimab overview

Cardinalizumab (Ketanil) is a bi-specific antibody acts as programmed death 1 protein (PD-1) antagonist and CTLA4 antagonist. It is formulated as solution for inravenous route of administration. Ketanil is indicated for the treatment of recurrent or metastatic cervical cancer (R/M CC) who had failed previous platinum-containing chemotherapy.

Cadonilimab is under development for the treatment of recurrent head and neck squamous cell carcinoma (including primary sites such as oral cavity, oropharynx, larynx or hypopharynx cancer), advanced or metastatic squamous or metastatic non-squamous non-small cell lung carcinoma, malignant pleural mesothelioma, fallopian tube cancer and primary peritoneal cancer, vaginal cancer, signet ring cell squamous cell carcinoma, adenocarcinoma of the gastroesophageal junction, adenosquamous cell carcinoma and solid tumors including cervical cancer, gastric cancer, hepatocellular carcinoma, esophageal squamous-cell carcinoma, locally recurrent and oligometastatic endometrial carcinoma, epithelial ovarian cancer, colorectal cancer, metastatic hormone refractory (castration resistant, androgen-independent) prostate cancer, transitional cell cancer (urothelial cell cancer), esophageal squamous cell carcinoma, triple-negative breast cancer, melanoma, mesothelioma, large-cell neuroendocrine carcinoma, colorectal cancer, non-small cell lung cancer small-cell lung cancer, melanoma, nasopharyngeal cancer, stomach cancer, urothelial carcinoma, metastatic soft tissue sarcoma, mainly including undifferentiated pleomorphic sarcoma/malignant fiber histiocytoma, alveolar soft part sarcoma, dedifferentiated liposarcoma, fibrosarcoma, leiomyosarcoma, angiosarcoma, synovial sarcoma, pancreatic ductal adenocarcinoma (PDAC), metastatic pancreatic cancer, vulvar cancer and metastatic clear cell renal cell carcinoma (ccRCC). It is administered by intravenous route. The drug candidate is a bi-specific monoclonal antibody. It acts by targeting programmed cell death protein 1 (PD-1) and Cytotoxic T Lymphocyte Protein 4 (CTLA4).

It was also under development for the treatment of peripheral T cell lymphoma.

Akeso overview

Akeso is a clinical-stage biopharmaceutical company that focuses on in-house discovery and development of mono and bi-specific antibody drugs. The company’s product pipeline includes Ak101 and Ak111 targeting plaque psoriasis; Ak102 for the treatment of hypercholesterolemia; Ak104 against cancer; Ak105 for treating anlotinib; and Ak112 against solid tumors. It also offers kangfang integrated development platform (ACE Platform) which covers all drug research and development, including target verification, antibody discovery and also development functions. The company works in partnership with MERCK & CO Inc, Dawnrays Pharmaceutical Holdings Ltd, Sino Biopharmaceutical Ltd and China Biopharma. Akeso is headquartered in Zhongshan, Guangdong, China

For a complete picture of Cadonilimab’s drug-specific PTSR and LoA scores, buy the report here.

GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.

GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.