Botensilimab is under clinical development by Agenus and currently in Phase II for Esophageal Cancer. According to GlobalData, Phase II drugs for Esophageal Cancer have a 25% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Botensilimab’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Botensilimab overview
AGEN-1181 is under development for the treatment of solid tumors including angiosarcoma and microsatellite stable tumors but not limited to PD-1-refractory non-small-cell lung cancer, ovarian cancer, esophageal squamous cell carcinoma, gastroesophageal junction adenocarcinoma, gastric cancer, breast cancer, prostate cancer, bladder cancer, head & neck SCC and MSS-colorectal cancer, renal cell carcinoma, metastatic castration-resistant prostate cancer (mCRPC), endometrial cancer, cervical cancer, hepatocellular carcinoma, pancreatic ductal adenocarcinoma, metastatic pancreatic cancer, leiomyosarcoma and colorectal cancer. The therapeutic candidate is administered through intravenous route. It is developed based on retrocyte display technology. The therapeutic candidate acts by targeting cytotoxic T lymphocyte-associated molecule-4 (CTLA-4).
It was also under development for the treatment of melanoma.
Agenus overview
Agenus, formerly, Antigenics, is a clinical-stage immuno-oncology company that discovers, develops and commercializes immunotherapeutics for the treatment of various types of cancers and infectious diseases. The company’s pipeline portfolio encompasses vaccines for glioblastoma, genital herpes, and multiple cancer types; vaccine adjuvants for the treatment of shingles and malaria; and checkpoint antibodies targeted at various diseases. The company’s technology portfolio includes antibody discovery platform, vaccine platforms and Heat Shock Protein (HSP) platform. It operates in the US and Europe. Agenus is headquartered in Lexington, Massachusetts, the US.
For a complete picture of Botensilimab’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
