BNT-323 is a monoclonal antibody conjugated commercialized by BioNTech, with a leading Phase III program in Metastatic Breast Cancer. According to Globaldata, it is involved in 4 clinical trials, of which 3 are ongoing, and 1 is planned. GlobalData uses proprietary data and analytics to provide a complete picture of BNT-323’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for BNT-323 is expected to reach an annual total of $102 mn by 2038 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
BNT-323 Overview
Trastuzumab pamirtecan (DB-1303) is under development for the treatment of advanced/unresectable, recurrent, or metastatic HER2-expressing malignant solid tumors, ovarian cancer, recurrent or metastatic endometrial carcinoma with HER2 overexpression, gastric, esophageal cancer, adenocarcinoma of the gastroesophageal junction, colorectal cancer, human epidermal growth factor receptor 2 positive breast cancer (her2 positive breast cancer), metastatic breast cancer, vaginal cancer, non-small cell lung cancer, adenocarcinoma . It is administered through intravenous route of administration. It is being developed based on DITAC platform. It acts by targeting Her2 expressing tumor cells and DNA topoisomerase I (Top I).
BioNTech Overview
BioNTech is a biotechnology company that develops immunotherapies for cancer and infectious diseases. The company’s primary activities involve harnessing the immune system to address diseases with unmet medical needs, utilizing a multi-technology innovation engine, GMP manufacturing, translational drug discovery, clinical development, commercial capabilities, computational medicine, data science, and artificial intelligence (AI) and machine learning (ML). BioNTech‘s product portfolio includes investigational mRNA vaccines, protein-based therapeutics, cell therapies, and small molecules. Its first marketed product is Comirnaty. The company’s products are designed to address the needs of cancer patients and combat infectious diseases. BioNTech collaborates with multiple global pharmaceutical companies, including Duality Biologics, Fosun Pharma, Genentech, Genevant, Genmab, OncoC4, Regeneron, and Pfizer. While the company operates globally, it aims to contribute to equitable access to medicine as part of its product strategy. BioNTech is headquartered in Mainz, Rhineland-Palatinate, Germany.
The company reported revenues of (Euro) EUR3,819 million for the fiscal year ended December 2023 (FY2023), a decrease of 77.9% over FY2022. In FY2023, the company’s operating margin was 18.1%, compared to an operating margin of 73% in FY2022. In FY2023, the company recorded a net margin of 24.4%, compared to a net margin of 54.5% in FY2022.
The company reported revenues of EUR128.7 million for the second quarter ended June 2024, a decrease of 31.4% over the previous quarter.
For a complete picture of BNT-323’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
