Bemcentinib is under clinical development by BerGenBio and currently in Phase II for Malignant Mesothelioma. According to GlobalData, Phase II drugs for Malignant Mesothelioma have a 42% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how Bemcentinib’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Bemcentinib overview
Bemcentinib (BGB-324, R-428) is under development for the treatment of inflammatory breast cancer, metastatic melanoma, relapsed/refractory acute myeloid leukaemia, myelodysplastic syndrome, STK11 mutated metastatic non-squamous non-small cell lung cancer including lung adenocarcinoma, malignant mesothelioma, glioblastoma, bladder cancer, acute respiratory distress syndrome and coronavirus disease 2019 caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), respiratory syncytial virus (RSV), influenza and rhinovirus infections. It is administered through oral route and acts by targeting Axl kinase. The drug candidate is a first-in-class selective AXL kinase inhibitor. The drug candidate is based on CellSelect Technology. It was also under development for chronic myelocytic leukemia, triple-negative breast cancer (TNBC), pancreatic ductal adenocarcinoma, liver fibrosis, recurrent glioblastoma, renal cell carcinoma, nonalcoholic steatohepatitis (NASH) and idiopathic pulmonary fibrosis.
BerGenBio overview
BerGenBio focuses on the development of transformative drugs built on AXL receptor tyrosine kinase (AXL) inhibitors for the treatment of therapy-resistant cancers. The company’s pipeline products include bemcentinib treats 1L STK11m non-small cell lung cancer (NSCLC) and acute respiratory distress syndrome (ARDS); Tilvestamab is for the treatment of fibrotic diseases; mipasetamab uzoptirine targets solid tumors. Tilvestamab is a functional blocking anti-AXL monoclonal antibody, which prevents AXL-mediated cell signaling in cancer cell lines, illustrates anti-tumor efficacy and decreases cell migration and invasion. BerGenBio is headquartered in Bergen, Norway.
For a complete picture of Bemcentinib’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
