Axitinib is a small molecule commercialized by Clearside BioMedical, with a leading Phase II program in Wet (Neovascular / Exudative) Macular Degeneration. According to Globaldata, it is involved in 4 clinical trials, of which 3 were completed, and 1 is planned. GlobalData uses proprietary data and analytics to provide a complete picture of Axitinib’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for Axitinib is expected to reach an annual total of $67 mn by 2036 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Axitinib Overview
Axitinib is under development for the treatment of choroidal neovascularization and wet age-related macular degeneration. The drug candidate is administered in suprachoroidal space through a micro needle. The drug candidate target both VEGF and PDGF. It is being developed based on Suprachoroidal space platform technology.
Clearside BioMedical Overview
Clearside BioMedical (Clearside) is a clinical biopharmaceutical company that develops treatments for vision impairment associated with uveitic macular edema. The company’s pipeline products comprise CLS-AX, XIPERE and SCS microinjectors. Clearside’s proprietary suprachoroidal treatment approach offers unprecedented access to the back of the eye where sight-threatening disease often occurs. The company also offers services such as business development, license agreements and contract manufacturing services. Clearside has partnered with various pharmaceutical companies for the commercialization and development of its products across the US, Canada, China, Hong Kong, Macau, Taiwan and South Korea, among others. It markets its products across the US. Clearside is headquartered in Alpharetta, Georgia, the US.
The company reported revenues of (US Dollars) US$8.2 million for the fiscal year ended December 2023 (FY2023), compared to a revenue of US$1.3 million in FY2022. The operating loss of the company was US$23.1 million in FY2023, compared to an operating loss of US$29.6 million in FY2022. The net loss of the company was US$32.5 million in FY2023, compared to a net loss of US$33 million in FY2022.
For a complete picture of Axitinib’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
