(Avibactam sodium + aztreonam) is under clinical development by Pfizer and currently in Phase III for Pyelonephritis. According to GlobalData, Phase III drugs for Pyelonephritis have an 89% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData’s report assesses how (Avibactam sodium + aztreonam)’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
(Avibactam sodium + aztreonam) overview
Avibactam sodium and Aztreonam (Emblaveo) is a fixed dose combination acts as antibacterial agents. It is formulated as concentrated solution for intravenous route of administration. Emblaveo is indicated for the treatment of hospital-acquired pneumonia, ventilator-acquired pneumonia, complicated intra-abdominal infections, complicated urinary tract infections, pyelonephritis. It is also indicated for the treatment of infections due to aerobic Gram-negative organisms in adult patients with limited treatment options.
PF-06947387 (aztreonam in combination with avibactam) is under development for the treatment of serious gram-negative bacterial infections caused by multiple-drug resistant pathogens producing metallo-beta-lactamases such as hospital-acquired pneumonia, ventilator-acquired pneumonia, complicated intra-abdominal infections, complicated urinary tract infections, pyelonephritis, peritonitis and bacterial pneumonia. The combination therapy is administered intravenously as a solution. It is a new molecular entity.
Pfizer overview
Pfizer discovers, develops, manufactures, and commercializes biopharmaceuticals. The company offers products to treat various conditions such as cardiovascular, metabolic and pain, women’s health, cancer, inflammation, immune disorders, and rare diseases. It also provides sterile injectable pharmaceuticals, biosimilars, active pharmaceutical ingredients (APIs) and contract manufacturing services. Pfizer sells its products through wholesalers, retailers, hospitals, individual provider offices, clinics, government agencies, and pharmacies. It has major manufacturing facilities in India, China, Japan, Ireland, Italy, Belgium, Germany, Singapore, and the US. The company provides its products in North America, South America, Asia-Pacific, Australia, Europe, Africa, and the Middle East. Pfizer is headquartered in New York, the US.
For a complete picture of (Avibactam sodium + aztreonam)’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
