ARCT-810 is under clinical development by Arcturus Therapeutics and currently in Phase II for Ornithine-Transcarbamylase Deficiency. According to GlobalData, Phase II drugs for Ornithine-Transcarbamylase Deficiency does not have sufficient historical data to build an indication benchmark PTSR for Phase II. GlobalData uses proprietary data and analytics to create drugs-specific PTSR and LoA in the ARCT-810 LoA Report. Buy the report here.
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GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
ARCT-810 overview
ARCT-810 is under development for the treatment of ornithine transcarbamylase (OTC) deficiency. It is administered through the intravenous route. The drug candidate is an ornithine transcarbamylase (OTC) mRNA. It is developed based on lipid-enabled and unlocked nucleic acid modified RNA delivery technology (LUNAR) a LNP based platform and manufactured by NanoAssemblr technology. It acts by targeting periportal hepatocytes.
Arcturus Therapeutics overview
Arcturus Therapeutics is a biotechnology company that develops messenger RNA (mRNA) medicines. It focuses on the discovery, development, and commercialization of medicines for the treatment of infectious diseases and rare diseases. The company’s major products include a lipid nanoparticle (LNP) delivery system, LUNAR, and mRNA technology. Its pipeline product portfolio includes ARCT-810 (LUNAR-OTC) and ARCT-032 (LUNAR-CF). LUNAR-CF is a grant program with the Cystic Fibrosis Foundation to treat cystic fibrosis using mRNA therapies. The company provides mRNA that is used as protein replacement therapy to treat diseases caused by a lack of protein or defective proteins, such as cystic fibrosis. Arcturus Therapeutics Inc is headquartered in San Diego, California, the US.
For a complete picture of ARCT-810’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
