Anhydrous enol oxaloacetate is under clinical development by MetVital and currently in Phase I for Amyotrophic Lateral Sclerosis. According to GlobalData, Phase I drugs for Amyotrophic Lateral Sclerosis have an 87% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData’s report assesses how Anhydrous enol oxaloacetate’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Anhydrous enol oxaloacetate overview
Anhydrous enol-oxaloacetate (AEO) is under development for the treatment of myasthenia gravis, amyotrophic lateral sclerosis (ALS), Alzheimer's disease, glioblastoma multiforme and for fatigue after resolution of COVID-19 infection. It is administered through oral route as a pill or capsule. The drug candidate acts by targeting AMP-protein activated Kinase (AMPK).
It was under development for the treatment of Parkinson's disease and traumatic brain injury, hepatocellular carcinoma.
MetVital overview
MetVital is a biopharmaceutical company developing small molecule modulators to improve cellular metabolism. Its lead product candidate AEO (Anhydrous Enol-Oxaloacetate), a patented small molecule reduces glutamate levels and protects the brain from excitotoxicity, a condition that kills brain cells. The company is advancing AEO development against glioblastoma multiforme, Alzheimer’s disease, Amyotrophic Lateral Sclerosis (ALS), breast cancer, hepatocellular carcinoma and other brain conditions. MetVital is headquartered in San Diego, California, the US.
For a complete picture of Anhydrous enol oxaloacetate’s drug-specific PTSR and LoA scores, buy the report here.
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