AnGes. has been granted a patent for a method to modify a mutant CXCR4 gene associated with WHIM syndrome. The method utilizes CRISPR technology, employing specific RNA molecules to selectively target and edit the mutant allele while preserving the expression of the functional CXCR4 protein. GlobalData’s report on AnGes gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on AnGes, NSAID cancer drugs was a key innovation area identified from patents. AnGes's grant share as of June 2024 was 35%. Grant share is based on the ratio of number of grants to total number of patents.
Crispr method for modifying cxcr4 gene mutations
The granted patent US12031149B2 outlines a method for modifying a mutant allele of the CXCR4 gene, which is associated with WHIM syndrome, without disrupting the expression of a functional CXCR4 protein. The method employs a CRISPR nuclease in conjunction with two RNA molecules. The first RNA molecule contains a guide sequence that specifically targets a single nucleotide polymorphism (SNP) in the mutant allele, while the second RNA molecule has a non-discriminatory guide sequence that targets the 3' untranslated region (UTR) of both the functional and mutant alleles. This dual-targeting approach allows for a double-strand break in the mutant allele, leading to the expression of only the functional CXCR4 protein in the cell.
Further claims detail the specific characteristics of the RNA molecules, including the length of the guide sequences (17-25 nucleotides) and their potential locations within the CXCR4 gene, such as promoter regions, 5' UTRs, or introns. The method also allows for the excision of portions of the CXCR4 mutant allele. Additionally, the patent specifies that the guide sequences can be derived from designated sequence identifiers, providing a framework for targeting specific SNP positions. Overall, this innovative method presents a targeted approach to gene editing that preserves the functionality of the CXCR4 gene while addressing mutations linked to WHIM syndrome.
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