23andMe Holding has been granted a patent for a method that utilizes identity-by-descent (IBD) data to construct and display genetic pedigrees. The system combines smaller pedigrees into larger graphs, enhancing the visualization of genetic relationships among individuals based on probabilistic models and pairwise data. GlobalData’s report on 23andMe Holding gives a 360-degree view of the company including its patenting strategy. Buy the report here.
According to GlobalData’s company profile on 23andMe Holding, was a key innovation area identified from patents. 23andMe Holding's grant share as of July 2024 was 46%. Grant share is based on the ratio of number of grants to total number of patents.
Methods for constructing and displaying genetic pedigrees
The granted patent US12073495B2 outlines a method for constructing and visualizing pedigrees of genetically related individuals using a computer system. The method involves iteratively growing pedigrees based on pairwise identity-by-descent (IBD) data, selecting which pedigrees to grow based on a configurable likelihood. It combines pairs of pedigrees that share significant common IBD data and stores the resulting pedigree relationship data in a database. The method further identifies root entries without known parents and forms subtrees for each root entry by positioning nodes that represent the relationships among individuals. These subtrees are then merged to create a comprehensive pedigree graph, which visually represents the genetic relationships among the individuals.
Additionally, the patent details specific techniques for positioning nodes within the subtrees, ensuring that parent nodes are appropriately placed relative to their child nodes. It describes methods for merging subtrees while avoiding overlap of non-corresponding nodes and includes provisions for enhancing the visual representation of the pedigree graph, such as using force-directed graph drawing techniques and applying color differentiation for parent nodes. The system is designed to facilitate the analysis and display of complex genetic relationships, making it a valuable tool for geneticists and researchers in the field of genetics.
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