23andMe has been granted a patent for binding proteins that target human IL-36 cytokines, blocking their signaling pathways. The patent includes specific sequences for anti-IL-36 antibodies. GlobalData’s report on 23andMe gives a 360-degree view of the company including its patenting strategy. Buy the report here.
According to GlobalData’s company profile on 23andMe, was a key innovation area identified from patents. 23andMe's grant share as of February 2024 was 47%. Grant share is based on the ratio of number of grants to total number of patents.
Anti-il-36 antibody for blocking il-36 cytokine signaling
A recently granted patent (Publication Number: US11884719B2) discloses an anti-IL-36 antibody with specific amino acid sequences in its light chain variable domain (VL) and heavy chain variable domain (VH). The antibody is designed to bind to hu-IL-36a, hu-IL-36-ß, and/or hu-IL-36-? with high binding affinity, inhibiting intracellular signals stimulated by these interleukins. The antibody also demonstrates the ability to decrease the release of IL-8 from primary human keratinocytes when stimulated by IL-36a, IL-36ß, and/or IL-36?. Furthermore, the patent includes claims for multispecific antibodies with distinct binding specificities for different IL-36 interleukins, as well as compositions comprising the antibody and a pharmaceutically acceptable carrier.
The patent also covers antibodies that exhibit cross-reactivity with IL-36 interleukins in cynomolgus monkeys, highlighting their potential for broader applications. Additionally, the disclosed antibodies are characterized by their ability to decrease intracellular signals stimulated by IL-36a, IL-36ß, or IL-36? by at least 90%, further underscoring their therapeutic potential. The specificity and binding affinity of the antibodies to different IL-36 interleukins, both in human and cynomolgus monkeys, are detailed in the patent claims, emphasizing the precision and versatility of these novel anti-IL-36 antibodies for potential therapeutic interventions targeting IL-36-mediated inflammatory responses.
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