Novartis has reported positive data from a real-world comparison study of its Jakavi (ruxolitinib) drug conducted to treat patients with polycythemia vera (PV), a rare incurable blood cancer.

Jakavi is an oral inhibitor of the JAK 1 and JAK 2 tyrosine kinases. The study showed a significant decline in the risk of thrombosis (blood clots) and death in PV patients who are resistant or intolerant to hydroxyurea, when compared to those treated using the ‘best available therapy’.

Go deeper with GlobalData

Data Insights

The gold standard of business intelligence.

Find out more

Related Company Profiles

View all

These results are based on comparing the Phase III RESPONSE Jakavi clinical trial participants and the real-world Spanish GEMFINI patient registry.

A separate efficacy analysis indicated reductions in spleen size reductions for those with lower-risk myelofibrosis (MF) patients treated with Jakavi, while another analysis detected factors related to better spleen response.

“The research conducted in both PV and MF is helping to clarify how Jakavi can help relieve disease burden for patients.”

Novartis Oncology Global Drug Development head Samit Hirawat said: “With limited treatment options, patients with myeloproliferative neoplasms often struggle to keep their disease under control.

“The research conducted by Novartis teams and our physician partners in both PV and MF is helping to clarify how Jakavi can help relieve disease burden for patients.”

How well do you really know your competitors?

Access the most comprehensive Company Profiles on the market, powered by GlobalData. Save hours of research. Gain competitive edge.

Company Profile – free sample

Thank you!

Your download email will arrive shortly

Not ready to buy yet? Download a free sample

We are confident about the unique quality of our Company Profiles. However, we want you to make the most beneficial decision for your business, so we offer a free sample that you can download by submitting the below form

By GlobalData
Visit our Privacy Policy for more information about our services, how we may use, process and share your personal data, including information of your rights in respect of your personal data and how you can unsubscribe from future marketing communications. Our services are intended for corporate subscribers and you warrant that the email address submitted is your corporate email address.

Jakavi secured the European Commission approval to treat adult PV patients who are resistant to or intolerant of hydroxyurea, and disease-related splenomegaly or symptoms in those with primary MF.

The drug currently has been approvaled in 101 countries for MF patients and in more than 75 countries to treat patients suffering from PV, with additional regulatory submissions underway in other markets.