CTX-131 is under clinical development by CRISPR Therapeutics and currently in Phase II for T-Cell Lymphomas. According to GlobalData, Phase II drugs for T-Cell Lymphomas have a 29% phase transition success rate (PTSR) indication benchmark for progressing into Phase III. GlobalData’s report assesses how CTX-131’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
CTX-131 overview
CTX-131 is under development for the treatment of metastatic, relapsed/refractory, clear cell renal cell carcinoma, cervical carcinoma, pancreatic adenocarcinoma, endometrial carcinoma, malignant pleural mesothelioma and relapsed and refractory hematologic malignancies including T cell lymphoma (TCL), B cell lymphoma (BCL), acute myeloid leukemia (AML) T cell lymphoma, mycosis fungoides (MF), Sezary syndrome (SS), peripheral T cell lymphoma (PTCL), angioimmunoblastic T cell lymphoma (AITL), adult T cell leukemia/lymphoma (ATLL) of leukemia, ALK+ anaplastic large cell lymphoma (ALCL), diffuse large B cell lymphoma (DLBCL), high-grade b-cell lymphoma, transformed marginal zone lymphoma(MZL), mantle cell lymphoma, myelodysplastic syndrome. The therapeutic candidate comprises of genetically modified allogeneic T cells expressing chimeric antigen receptors targeting CD70. It is administered through intravenous route and is being developed based on CRISPR/Cas9 gene-editing technology.
CRISPR Therapeutics overview
CRISPR Therapeutics is a gene editing company. The company’s portfolio consists of multiple therapeutic programs, including its proprietary technology, CRISPR (Clustered, Regularly Interspaced Short Palindromic Repeats)/Cas9 (CRISPR-associated protein-9), to precisely alter specific sequences of genomic deoxyribonucleic acid (DNA). The company’s products are primarily used in the healthcare industry, specifically in the treatment and prevention of both rare and common diseases. Its portfolio includes multiple therapeutic programs in areas such as hemoglobinopathies, immuno-oncology, autoimmune diseases, and type 1 diabetes. The company’s advanced program, Casgevy, is approved for treating severe sickle cell disease (SCD) and transfusion-dependent beta-thalassemia (TDT). CRISPR Therapeutics is headquartered in Zug, Switzerland.
For a complete picture of CTX-131’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
