Phentolamine mesylate is under clinical development by Opus Genetics and currently in Phase III for Presbyopia. According to GlobalData, Phase III drugs for Presbyopia have a 75% phase transition success rate (PTSR) indication benchmark for progressing into Pre-Registration. GlobalData’s report assesses how Phentolamine mesylate’s drug-specific PTSR and Likelihood of Approval (LoA) scores compare to the indication benchmarks. Buy the report here.
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval.
Phentolamine mesylate overview
Phentolamine mesylate (Ryzumvi) is an antihypertensive agent. It is formulated as solution for ophthalmic route of administration. Ryzumvi is indicated for the treatment of pharmacologically-induced mydriasis produced by adrenergic agonists (e.g., phenylephrine) or parasympatholytic (e.g., tropicamide) agents.
Phentolamine mesylate is under development for the treatment of presbyopia. Phentolamine mesylate (Nyxol eye drops) targets alpha-1 and alpha-2 adrenergic receptors. It was also under development for the treatment of open-angle glaucoma (OAG) and ocular hypertension (OHT).
Opus Genetics overview
Opus Genetics is a clinical-stage biopharmaceutical company that develops novel therapies for retinal and refractive eye disorders. The company’s product candidates include APX3330, a small-molecule inhibitor of Ref-1, and Phentolamine Ophthalmic Solution 0.75% (PS), an eye drop formulation of phentolamine mesylate. Its APX3330 is being developed for the treatment of diabetic retinopathy and diabetic macular edema. The company markets its products under the brand RYZUMVI. Opus Genetics‘ products are aimed at addressing the unmet needs of patients with various eye disorders, including those suffering from diabetic retinopathy, a condition that affects millions of diabetics worldwide. The company collaborates with Viatris, Inc. for the development and commercialization of its refractive product candidate. Opus Genetics is headquartered in Farmington Hills, Michigan, the US.
For a complete picture of Phentolamine mesylate’s drug-specific PTSR and LoA scores, buy the report here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s Pharmaceutical Intelligence Center.
