CTX-112 is a gene-modified cell therapy commercialized by CRISPR Therapeutics, with a leading Phase II program in Diffuse Large B-Cell Lymphoma;Mantle Cell Lymphoma;Follicular Lymphoma;B-Cell Non-Hodgkin Lymphoma;B-Cell Chronic Lymphocytic Leukemia;Marginal Zone B-cell Lymphoma. According to Globaldata, it is involved in 2 clinical trials, which are ongoing. GlobalData uses proprietary data and analytics to provide a complete picture of CTX-112’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for CTX-112 is expected to reach an annual total of $12 mn by 2039 in the US based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
CTX-112 Overview
CTX-112 is under development for the treatment of relapsed and refractory B-cell malignancies including non-Hodgkin lymphoma, chronic lymphocytic leukemia, small lymphocytic leukemia, follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma, diffuse large B-cell lymphoma and systemic lupus erythematosus (SLE). The therapeutic candidate (CAR-T) comprises of genetically modified allogeneic T cells expressing chimeric antigen receptors targeting cells expressing B lymphocyte antigen CD19. It is administered through intravenous route and is being developed based on CRISPR's gene-editing technology.
CRISPR Therapeutics Overview
CRISPR Therapeutics is a gene editing company. The company’s portfolio consists of multiple therapeutic programs, including its proprietary technology, CRISPR (Clustered, Regularly Interspaced Short Palindromic Repeats)/Cas9 (CRISPR-associated protein-9), to precisely alter specific sequences of genomic deoxyribonucleic acid (DNA). The company’s products are primarily used in the healthcare industry, specifically in the treatment and prevention of both rare and common diseases. Its portfolio includes multiple therapeutic programs in areas such as hemoglobinopathies, immuno-oncology, autoimmune diseases, and type 1 diabetes. The company’s advanced program, Casgevy, is approved for treating severe sickle cell disease (SCD) and transfusion-dependent beta-thalassemia (TDT). CRISPR Therapeutics is headquartered in Zug, Switzerland.
The company reported revenues of (US Dollars) US$371.2 million for the fiscal year ended December 2023 (FY2023), compared to a revenue of US$1.2 million in FY2022. The operating loss of the company was US$222.5 million in FY2023, compared to an operating loss of US$673.2 million in FY2022. The net loss of the company was US$153.6 million in FY2023, compared to a net loss of US$650.2 million in FY2022.
The company reported revenues of US$0.5 million for the second quarter ended June 2024, an increase of 2.6% over the previous quarter.
For a complete picture of CTX-112’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
