Sonrotoclax is a small molecule commercialized by BeiGene, with a leading Phase III program in Chronic Lymphocytic Leukemia (CLL). According to Globaldata, it is involved in 19 clinical trials, of which 2 were completed, 11 are ongoing, and 6 are planned. GlobalData uses proprietary data and analytics to provide a complete picture of Sonrotoclax’s valuation in its risk-adjusted NPV model (rNPV). Buy the model here.
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The revenue for Sonrotoclax is expected to reach an annual total of $53 mn by 2034 globally based off GlobalData’s Expiry Model. The drug’s revenue forecasts along with estimated costs are used to measure the value of an investment opportunity in that drug, otherwise known as net present value (NPV). Applying the drug’s phase transition success rate to remaining R&D costs and likelihood of approval (LoA) to sales related costs provides a risk-adjusted NPV model (rNPV). The rNPV model is a more conservative valuation measure that accounts for the risk of a drug in clinical development failing to progress.
Sonrotoclax Overview
Sonrotoclax is under development for the treatment of relapsed and refractory multiple myeloma, B-cell malignancies such as nodal, extranodal, splenic marginal zone lymphoma, mantle cell lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), myeloproliferative disorders, chronic myelomonocytic leukemia (CMML), breast cancer and waldenstrom macroglobulinemia. It is administered through oral route. The drug candidate acts by targeting pro-apoptotic protein Bcl-2.
BeiGene Overview
BeiGene is a biotechnology company. It specializes in the development and commercialization of immuno-oncology medicines to treat cancers. The company offers Zanubrutinib, a small molecule inhibitor to treat various blood cancers and Sonrotoclax, a small molecule Bcl-2 inhibitor for treating chronic lymphocytic leukemia. BeiGene also provides Tislelizumab (BGB-A317), a monoclonal antibody targeting solid tumors and hematologic cancer; and Pamiparib (BGB-290) against solid tumor malignancies. The company has operations in the US, Australia, Germany, Spain, Canada, Switzerland and Italy. BeiGene is headquartered in the Cayman Islands.
The company reported revenues of (US Dollars) US$2,458.8 million for the fiscal year ended December 2023 (FY2023), an increase of 73.7% over FY2022. The operating loss of the company was US$844.8 million in FY2023, compared to an operating loss of US$1,789.7 million in FY2022. The net loss of the company was US$881.7 million in FY2023, compared to a net loss of US$2,003.8 million in FY2022.
The company reported revenues of US$929.2 million for the second quarter ended June 2024, an increase of 23.6% over the previous quarter.
For a complete picture of Sonrotoclax’s valuation, buy the drug’s risk-adjusted NPV model (rNPV) here.
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GlobalData, the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article.
To create this model, GlobalData takes into account factors including patent law, known and projected regulatory approval processes, cash flows, drug margins and company expenses. Combining these data points with GlobalData’s world class analysis creates high value models that companies can use to help in evaluation processes for each drug or company.
The rNPV method integrates the probability of a drug reaching a clinical stage into the cash flow at that time, which provides a more accurate valuation, as it considers the probability that the drug never makes it through the clinical pathway to commercialization. GlobalData’s rNPV model uses proprietary likelihood of approval (LoA) and phase transition success rate (PTSR) data for the indication in the highest development stage, which can be found on GlobalData’s Pharmaceutical Intelligence Center.
