Eiger BioPharmaceuticals. has been granted a patent for a method to treat hepatitis delta virus (HDV) infection using a combination of lonafarnib and ritonavir. The treatment involves administering an amorphous co-precipitate of these compounds, which is free of crystalline forms, at specified daily doses. GlobalData’s report on Eiger BioPharmaceuticals gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Eiger BioPharmaceuticals, Peptide pharmacophores was a key innovation area identified from patents. Eiger BioPharmaceuticals's grant share as of July 2024 was 28%. Grant share is based on the ratio of number of grants to total number of patents.
Combination treatment for hepatitis delta virus (hdv) infection
The granted patent US12029819B2 outlines a method for treating hepatitis delta virus (HDV) infections in human patients through the oral administration of an amorphous co-precipitate. This co-precipitate consists of lonafarnib or its pharmaceutically acceptable salt, combined with ritonavir or its pharmaceutically acceptable salt. Notably, the formulation is designed to be substantially free of crystalline forms, enhancing its therapeutic efficacy. The recommended daily dosage of lonafarnib ranges from 50 mg to 200 mg, which can be administered once or twice daily. The treatment duration can vary, with options for administration lasting from 30 days to the patient's lifetime, contingent upon the effectiveness in maintaining HDV at a low level.
Additionally, the patent specifies that the amorphous co-precipitate may be formulated into various dosage forms, including tablets, caplets, gelcaps, or capsules. The co-precipitate's composition may also include a gastrointestinal modifying agent to improve absorption or efficacy. The claims further emphasize the potential for treating chronic HDV infections, with specific ratios of lonafarnib to ritonavir ranging from 0.5:1 to 2:1 by weight. This innovative approach aims to provide a meaningful therapeutic benefit for patients suffering from HDV, addressing a significant medical need in the management of this viral infection.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
