Zeria Pharmaceutical has been granted a patent for antibody molecules and functional fragments that bind to tumor necrosis factor alpha (TNFa). The patent details specific amino acid sequences for the variable light (VL) and variable heavy (VH) domains of these antibodies, outlining their potential therapeutic applications. GlobalData’s report on Zeria Pharmaceutical gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Zeria Pharmaceutical, Cancer treatment biomarkers was a key innovation area identified from patents. Zeria Pharmaceutical's grant share as of July 2024 was 45%. Grant share is based on the ratio of number of grants to total number of patents.
Antibody binding to tumor necrosis factor alpha (tnfa)
The patent US12043663B2 describes a novel antibody or functional fragment that specifically binds to human tumor necrosis factor alpha (TNFa). The claims detail various structural configurations of the antibody, including specific amino acid sequences for the variable light (VL) and variable heavy (VH) domains, which are critical for its binding affinity. The patent outlines multiple embodiments of the antibody, including single-chain variable fragments (scFv) and immunoglobulin G (IgG), with binding affinities characterized by dissociation constants (KD) of less than 125 pM for human TNFa and less than 1 nM for TNFa from Macaca fascicularis. Additionally, the antibody demonstrates enhanced potency in inhibiting TNFa-induced apoptosis compared to existing treatments like infliximab.
Furthermore, the patent encompasses methods for producing the antibody, including culturing cells that express the nucleic acid encoding the antibody and recovering the functional product. It also includes claims for pharmaceutical compositions containing the antibody, which can be used to treat inflammatory disorders, particularly those related to TNFa, such as inflammatory bowel disease, Crohn's disease, and ulcerative colitis. The claims emphasize the potential therapeutic applications of the antibody in managing conditions characterized by excessive TNFa activity, highlighting its relevance in the field of immunology and therapeutic development.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
