Sun Pharmaceutical Industries has been granted a patent for methods to prepare deuterated analogs of D-serine, specifically focusing on the preparation of D-serine-2-d. The patent outlines both the methods and compounds useful in this process. GlobalData’s report on Sun Pharmaceutical Industries gives a 360-degree view of the company including its patenting strategy. Buy the report here.
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According to GlobalData’s company profile on Sun Pharmaceutical Industries, Nanoparticle drug conjugates was a key innovation area identified from patents. Sun Pharmaceutical Industries's grant share as of July 2024 was 35%. Grant share is based on the ratio of number of grants to total number of patents.
Method for preparing deuterated d-serine analogs
The granted patent US12065395B2 outlines a method for preparing D-serine-2-d, detailing specific chemical processes and compounds involved in the synthesis. The method includes the use of a compound referred to as Formula E, where variations in the substituent R2 can include C1-C6 alkyl groups, specifically isopropyl or t-butyl. Additionally, the method allows for the incorporation of a protecting group R3, which can be selected from a range of chemical structures, including various acyl and aryl groups. The patent also specifies the use of hydrochloric acid in the process and outlines steps for removing the amine-protecting group and opening an oxazolidine ring, which are critical for the successful synthesis of the target compound.
Further claims in the patent detail the preparation of compounds represented by specific structures, including the use of various bases and deuterium sources in the reaction mixture. The patent emphasizes the flexibility in choosing protecting groups and bases, with examples including lithium deuteroxide and a variety of lithium-based reagents. The claims also specify the potential compounds that can be synthesized, including multiple derivatives of compound 50. Overall, the patent provides a comprehensive framework for the synthesis of D-serine-2-d and related compounds, highlighting the versatility and specificity of the chemical methods involved.
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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies
