Mallinckrodt has been granted a patent for a photopheresis system that includes protocols for air purging in centrifuge bowls, assessing pressure dome operations, and collecting buffy coat from processed blood. The method involves monitoring blood separation and conditions within the centrifuge to direct fluid flow effectively. GlobalData’s report on Mallinckrodt gives a 360-degree view of the company including its patenting strategy. Buy the report here.

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According to GlobalData’s company profile on Mallinckrodt, was a key innovation area identified from patents. Mallinckrodt‘s grant share as of July 2024 was 57%. Grant share is based on the ratio of number of grants to total number of patents.

Blood processing method using a centrifuge for photopheresis

Source: United States Patent and Trademark Office (USPTO). Credit: Mallinckrodt Plc

The patent US12064544B2 outlines a method for operating a blood processing system that includes a centrifuge designed to separate blood into distinct layers: plasma, buffy coat, and red blood cells. The method involves introducing blood through a first port into the centrifuge, where it is then rotated to facilitate separation. Key steps include monitoring the interface between the buffy coat and red blood cell layers, as well as assessing specific conditions related to the volume of blood processed. The system directs fluid flow from a second port into a container, specifically extracting the buffy coat when certain conditions are met, such as the volume of blood being less than or greater than a predetermined target.

Further enhancements to the method include additional monitoring steps to assess hematocrit levels in the fluid flow, which can influence the continuation or suspension of the fluid flow process. The system is designed to utilize a disposable kit that includes the centrifuge and container, and it incorporates user input for activating a blood prime function. This function allows for the introduction of donor blood before patient blood, with safeguards in place to prevent the transfer of contents back to the patient during specific operational phases. The method also includes provisions for photo therapy of the collected blood, ensuring that the system operates efficiently and safely throughout the blood processing procedure.

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GlobalData Patent Analytics tracks bibliographic data, legal events data, point in time patent ownerships, and backward and forward citations from global patenting offices. Textual analysis and official patent classifications are used to group patents into key thematic areas and link them to specific companies